CurQnetic™ Bioavailable Curcumin
CurQnetic™ Bioavailable Curcumin
CurQnetic™ Bioavailable Curcumin
Plant Part Used
CurQnetic™ is an enriched Curcumin extract (95%) from Turmeric root.
Traditional Use
Curcumin is derived from Turmeric, a spice widely used in Indian cooking. Turmeric gives curries their yellow color and distinctive mustard-like taste. In addition to it culinary uses, Turmeric is used in Ayurveda, the traditional medicine system of India, for wound healing and to support liver, joint, and respiratory health.*1Jacob CV, et al. Bioavailability and activity of a Curcumin formulation CurQnetic™. Unpublished paper.
Phytochemistry
Curcumin is one of three constituents contained within Turmeric called Curcuminoids. The other two are Demethoxycurcumin and Bisdemethoxycurcumin. The most active of all three Curcuminoids, Curcumin gives Turmeric its yellow color and is responsible for most of its therapeutic effects.
Pharmacology
Standard Curcumin has extremely low bioavailability; it is both poorly absorbed and distributed through the body. What little Curcumin is absorbed becomes quickly excreted through a process called glucuronidation. This process happens when glucuronic acid is added to a substance, which aids its swift elimination from the body.
CurQnetic™ solves the bioavailability problem by combining Curcumin with vanillin from vanilla and gingerols from ginger. Because these compounds are structurally similar to Curcumin, they help it bypass the glucuronidation process. A bioavailability study in rats showed that CurQnetic™ had 8 times the absorption of standard Curcumin and stayed in the body 6 times longer — a full 24 hours.
Indications
- Encourages a healthy response to inflammation*
- Supports the health of colon and pancreas cells*
- Improves antioxidant status*
- Protects cellular DNA from free radical damage*
- Helps maintain cholesterol levels already within a healthy range*
- Helps maintain the health and integrity of the intestinal lining*
- Supports joint comfort and promotes joint function*
Research
Inflammation Response
Multiple double-blind human clinical studies have shown that Curcumin promotes a healthy inflammation response.*2Chainani-Wu N, et al. J Am Acad Dermatol. 2012 May;66(5):752-60.3Khajehdhl P, et al. J Ren Nutr. 2012 Jan;22(1):50-7. Research on CurQnetic™ in rats showed a significant effect in less than 3 hours.*4Jacob CV, et al. Bioavailability and activity of a Curcumin formulation CurQnetic™. Unpublished paper.
Colon Health
Human research indicates Curcumin supports the health of colon cells by upregulating P53 expression.*5He ZY, et al. Cancer Invest. 2011 Mar;29(3):208-13. Research on CurQnetic™ in mice suggests the ingredient’s increased bioavailability enhances its protective effect on colon cells.*6Jacob CV, et al. Bioavailability and activity of a Curcumin formulation CurQnetic™. Unpublished paper.
Antioxidant Protection
Curcumin has potent antioxidant activity, increasing several important antioxidant enzymes, some by as much as 40%.*7DiSilvestro RA, et al. Nutr J. 2012 Sep 26;11:79.8Kalpravidh RW, et al. Clin Biochem. 2010 Mar;43(4-5):424-9. In one study of an Indian community drinking groundwater tainted by arsenic, supplementation with Curcumin over three months helped maintain the integrity of DNA.*9Biswas J, et al. Hum Exp Toxicol. 2010 Jun;29(6):513-24.
Blood Lipid Balance
Human research in susceptible populations suggests Curcumin may help maintain LDL cholesterol, HDL cholesterol, and triglycerides already within healthy limits.*10Alwi I, et al. Acta Med Indones. 2008 Oct;40(4):201-10.11Adab Z, et al. Phytother Res. 2019 Apr;33(4):1173-1181.12Na X, et al. Mol Nutr Food Res. 2013 Sep;57(9):1569-77.
Intestinal Health
One pilot study and a larger, double-blind, placebo-controlled 6-month human clinical trial found Curcumin increased intestinal comfort and protected the structure of the intestinal lining.*13Holt PR, Katz S, Kirshoff R. Dig Dis Sci. 2005 Nov;(11):2191-3.14Hanal H, et al. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
Joint Health
Curcumin has also been shown effective at supporting joint health, comfort, and function in multiple human clinical trials.*15Panahi Y, et al. Phytother Res. 2014 Nov;28(11):1625-31.16Kuptniaratsaikul V, et al. J Altern Complement Med. 2009 Aug;15(8):891-7.17Madhu K, Chandra K, Saji MJ. Inflammopharamacology. 2013 Apr;21(12):129-36.18Nakagawa Y, et al. J Orthrop Sci. 2014 Nov;19(6):933-9. One study found a decrease in C-reactive protein in a subgroup with high baseline levels.*19Belcaro G, et al. Panminerva Med. 2010 Jun;52(2Suppl 1):55-62.
Mechanism of Action
When Curcumin is successfully absorbed and retained, it promotes a healthy inflammation response by modulating the synthesis of eicosanoids (signaling molecules), as well as the activity of transcription factor NF-kB.* It also increases the body’s production of endogenous antioxidants.*
Dosage
Human studies of Curcumin have used doses ranging from 45 mg to 6 g per day.
Safety
Curcumin is derived from Turmeric, a spice that has been widely and safely consumed throughout Asia for thousands of years. Human safety studies indicate it is non-toxic, even at very high doses (up to 12 grams a day). However, doses of 3.6 grams of Turmeric daily may cause mild gastrointestinal discomfort.20Lao CD, et al. BMC Complement Alter Med. 2006;6:10.21Sharma RA, et al. Clin Cancer Res. 2004;10(20):6847-54.
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Bioavailable Curcumin
Bioavailable Curcumin
Full spectrum 95% Curcumin
CurQnetic™ Benefits
- Highly bioavailable: Up to 8x the oral bioavailability of regular Curcumin.
- Excellent retention: Retained in the bloodstream 6x longer than regular Curcumin, providing 24-hour bioactivity.
- Preclinically studied: Powerful biological activity, as demonstrated in several in vitro and in vivo efficacy studies.
- Enriched: 95% Curcumin — as verified by HPLC testing — so lower dosage is needed due to greater potency.
- Ecologically extracted: Extracted using only eco-friendly food-grade solvents such as ethyl acetate.
- Complete traceability: Traceable from farm to finished ingredient.
- Vertically integrated: Integrated from cultivation to manufacturing.
- Sustainable supply: Produced by the largest processor of Curcumin in India, guaranteeing a sustainable supply of Turmeric raw material.
- Accredited: Manufactured according to ISO, cGMP, HAACP, and PMDA requirements.
- Certified: Certified Kosher, Parve, and Halal.
Why Standard Curcumin Is Not Bioavailable
Curcumin bioavailability is notoriously poor for two reasons:
- Curcumin is poorly absorbed and distributed in the body. As a result, very little Curcumin makes it into the bloodstream and tissues.
- What little Curcumin is absorbed becomes rapidly metabolized through a process called glucuronidation. (Glucuronidation involves the addition of glucuronic acid to a substance, which facilitates its elimination from the body.)
You may be wondering how to increase bioavailability of Curcumin. Unibar, a pioneer in the development of enhanced bioavailability Curcumin, has the answer: Bypass the glucuronidation reaction altogether.
CurQnetic™ Bioavailable Curcumin
CurQnetic™ incorporates Curcumin (95%) from pure Indian-grown Turmeric with vanillin (from vanilla) and gingerols (from ginger), which share certain key molecular structural features with Curcumin. The vanillin and gingerol thus act as adjuvants, helping Curcumin to bypass the glucuronidation reaction. This action increases Curcumin absorption and retention.
How CurQnetic™ is Made
Unibar oversees the production of CurQnetic™ from farm to finished ingredient.
- Farmers in India are contracted to grow Turmeric.
- Cultivation is closely supervised, and farms are provided with cultivation and post-harvest handling assistance.
- The harvested Turmeric is brought directly to a state-of-the-art manufacturing facility.
- Turmeric quality is confirmed at our in-process lab using an array of cutting edge analytical equipment.
- After the Turmeric has passed each and every quality control test, it is extracted in a closed-loop manufacturing process to concentrate the Curcuminoids.
- The end result of this carefully controlled process is a Curcuminoids concentrate that retains the sensory qualities and range of constituents present in the fresh Turmeric rhizomes.
- The Curcuminoids are then blended with vanillin and gingerols in a proprietary, patented composition.
Curcumin Health Benefits
Turmeric is a culinary and medicinal herb that has been used in India for over 2,500 years. Research has identified Curcumin as the active ingredient of Turmeric responsible for its bioactivity. Over the past 30 years, dozens of human clinical studies have been published examining the potential health benefits of Curcumin from Turmeric.
Results of these studies have shown that Curcumin:
- Encourages a healthy response to inflammation*
- Supports the health of colon and pancreas cells*
- Improves antioxidant status*
- Protects cellular DNA from free radical damage*
- Helps maintain cholesterol levels already within a healthy range*
- Helps maintain the health and integrity of the intestinal lining*
- Supports joint comfort and promotes joint function*
We’ve done the research for you
Don’t just take our word for it, see the science and studies behind CurQnetic.
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
